In collaboration with families of children and youth with special health care needs, health care professionals, public health leaders, researchers, academic institutions, and other Federal partners, the Maternal and Child Health Bureau recently released a Blueprint for Change, a national framework to improve care for the nearly one in five children in the United States who currently has a special health care need. The series of 7 articles include detailed discussions of four critical areas for change: health equity, family and child well-being and quality of life, access to services, and financing of services.