This brief addresses the implications—both promising and troubling—of integrating adversity screening into child and family service settings that are not exclusively focused on mental health. It summarizes how the research has both informed work with vulnerable children and families, and inadvertently provided a rationale for a strategy that could do harm through the singular use of screening to address the negative effects of childhood adversity. It recommends steps to minimize the unintended consequences of screening and provide a more comprehensive, holistic response to children who have experienced adversity.